Pupal fat body cells recruited to skin wounds
Pupal fat body cells are motile cells that are recruited to skin wounds. This movie shows one fat body cell approaching an epithelial wound and forming a tight bond with the wound gap until wound re-epithelialisation is complete. Other fat body cells appear later and are seen patrolling in the vicinity. Fat body cells are shown in green (c564-Gal4+UAS-GFP) and epithelial nuclei in red (Ubq>Histone-RFP). Projection and Z plane views are shown on the left and right, respectively. Elapsed time is in top right corner in hours:minutes:seconds. Scale bar, 20 μm
Anna Franz, Will Wood and Paul Martin (2018)
Fat body cells are motile and actively migrate to wounds to drive repair and prevent infection.
Dev Cell. 2018 Feb 26; 44(4):460-470.e3
Reconstruction of Neurons from an Electron Microscopy Volume of the Entire Adult Fruit Fly Brain
The neural basis for behavior and decision-making is defined, in part, by the wiring diagram between neurons in the brain. Zheng, Lauritzen et al. present a whole-brain electron microscopy image dataset of an adult fruit (or vinegar) fly, Drosophila melanogaster, sufficient to trace the synaptic connectivity of any selected brain circuit in this genetic model organism. In the image, a reconstruction of neurons from the volume are colored according to their soma locations. Over 20 labs have collectively reconstructed ~7 meters of cable length, ~5% of total in brain.
EM reconstruction of Drosophila neurons by the Full Adult Fly tracing community.
Image Credit: Philipp Schlegel (Drosophila Connectomics Group, Cambridge)
Zheng Z, Lauritzen JS, Perlman E, Robinson CG, Nichols M, Milkie D, Torrens O, Price J, Fisher CB, Sharifi N, Calle-Schuler SA, Kmecova L, Ali IJ, Karsh B, Trautman ET, Bogovic JA, Hanslovsky P, Jefferis GSXE, Kazhdan M, Khairy K, Saalfeld S, Fetter RD, Bock DD (2018)
A Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster.
Cell. 2018 Jul 26;174(3):730-743